5'-Methylthioadenosine-13C5

5'-Methylthioadenosine-13C5 (5'- (Methylthio) -5'-deoxyadenosine-13C5) is the 13C--labeled 5'-Methylthioadenosine (HY-16938) . 5'-Methylthioadenosine (5'- (Methylthio) -5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

Product Specifications

Product Name Alternative

5'- (Methylthio) -5'-deoxyadenosine-13C5; 5'-Deoxy-5'- (methylthio) adenosine-13C5; 5'-S-Methyl-5'-thioadenosine-13C5

Target

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; Parasite

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Metabolic Disease

Smiles

NC1=NC=NC2=C1N=CN2[13C@]3([H])O[13C@H]([13CH2]SC)[13C@@H](O)[13C@H]3O

Molecular Formula

C6 13C5H15N5O3S

Molecular Weight

302.30

References & Citations

[1]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.|[2]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37 (5) :1366-1373.