Mavatrep (Standard)

Mavatrep (Standard) is the analytical standard of Mavatrep. This product is intended for research and analytical applications. Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM) . Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].

Product Specifications

CAS Number

[956274-94-5]

UNSPSC

12352100

Target

Reference Standards; TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2

Molecular Formula

C25H21F3N2O

Molecular Weight

422.44

References & Citations

[1]Parsons W H, et al. Benzo [d] imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2- (2-{2-[2- (4-Trifluoromethyl-phenyl) -vinyl]-1 H-benzimidazol-5-yl}-phenyl) -propan-2-ol (Mavatrep) . Journal of medicinal chemistry, 2015, 58 (9) : 3859-3874.