RP-182-PEG3-K (palmitic acid) (TFA)

RP-182-PEG3-K (palmitic acid) (Compound 1a) TFA is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K (palmitic acid) TFA inhibits CD206high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K (palmitic acid) TFA exhibits antitumor efficacy in mouse B16 melanoma allografts[1].

Product Specifications

UNSPSC

12352209

Target

Drug Derivative

Related Pathways

Others

Field of Research

Cancer

Smiles

C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CC=CC=C1)=O)CCCNC(N)=N)=O)CCCCN)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCCOCCOCCOCC(N[C@H](C(N)=O)CCCCNC(CCCCCCCCCCCCCCC)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)=O)CC4=CC=CC=C4)=O.O=C(O)C(F)(F)F.[x]

Molecular Formula

C99H161N23O16.xC2HF3O2

Molecular Weight

1929.48 (free base)

References & Citations

[1]Singh SS, et al., Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity. Mol Cancer Ther. 2024 Aug 30.