RP-182-PEG3-K (palmitic acid) (TFA)
RP-182-PEG3-K (palmitic acid) (Compound 1a) TFA is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K (palmitic acid) TFA inhibits CD206high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K (palmitic acid) TFA exhibits antitumor efficacy in mouse B16 melanoma allografts[1].
Product Specifications
UNSPSC
12352209
Target
Drug Derivative
Related Pathways
Others
Field of Research
Cancer
Smiles
C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CC=CC=C1)=O)CCCNC(N)=N)=O)CCCCN)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCCOCCOCCOCC(N[C@H](C(N)=O)CCCCNC(CCCCCCCCCCCCCCC)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)=O)CC4=CC=CC=C4)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C99H161N23O16.xC2HF3O2
Molecular Weight
1929.48 (free base)
References & Citations
[1]Singh SS, et al., Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity. Mol Cancer Ther. 2024 Aug 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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