Yck2-IN-1

Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes) . In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection[1].

Product Specifications

CAS Number

[401816-26-0]

UNSPSC

12352101

Target

Casein Kinase; Fungal

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Stem Cell/Wnt

Field of Research

Infection

Smiles

N#CC1=CN2N=C(C(C3=CC=NC=C3)=C2C=C1)C4=CC=C(C=C4)F

Molecular Formula

C19H11FN4

Molecular Weight

314.32

References & Citations

[1]Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16 (1) :2156.