Yck2-IN-1
Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes) . In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection[1].
Product Specifications
CAS Number
401816-26-0
UNSPSC
12352101
Target
Casein Kinase; Fungal
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Infection
Smiles
N#CC1=CN2N=C(C(C3=CC=NC=C3)=C2C=C1)C4=CC=C(C=C4)F
Molecular Formula
C19H11FN4
Molecular Weight
314.32
References & Citations
[1]Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16 (1) :2156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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