CB1R agonist 1
CB1R agonist 1 (Compound '1350') is a potent full agonist of the cannabinoid-1 receptor (CB1R), with a Ki value of 0.95 nM. CB1R agonist 1 exhibits significant pain-reducing effects in multiple pain models, including acute heat pain, inflammatory pain, and neuropathic pain[1].
Product Specifications
UNSPSC
12352211
Target
Cannabinoid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease; Inflammation/Immunology
Smiles
COC([C@@](NC(C1=NN(C(C)=C1)C2=CC(C(F)(F)F)=CC=C2)=O)(C3=CC=CS3)C)=O
Molecular Formula
C20H18F3N3O3S
Molecular Weight
437.44
References & Citations
[1]Tummino TA, et al. Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects. Nat Commun. 2025 Mar 6;16 (1) :2237.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1
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