BAR-072
BAR-072 is a small-molecule inhibitor targeting TraE, with a KD of 2.7 µM. It significantly inhibits the transfer of the antibiotic resistance-associated plasmid pKM101. BAR-072 shows promise as a candidate compound for blocking the spread of bacterial resistance genes and holds potential for research in infectious disease and antimicrobial resistance control[1].
Product Specifications
CAS Number
2068867-65-0
UNSPSC
12352211
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(C1=C(C=CC(O)=C1)O)N/N=C/C2=CC=C(O2)C3=CC=CC=C3[N+]([O-])=O
Molecular Formula
C18H13N3O6
Molecular Weight
367.31
References & Citations
[1]Casu B, et al. Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System. J Biol Chem. 2016 Nov 4;291 (45) :23817-23829.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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