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Ontunisertib

Ontunisertib (Example 26) is an inhibitor of TGFβ receptor I/ALK5 (TGFβRI/ALK5), with IC50 values ranging from 100 to 500 nM for TGFβRI and an IC50 value of ≤100 nM for ALK5. Ontunisertib can be used in research on gastrointestinal diseases, as well as diseases and cancers related to fibrotic conditions in the skin and eyes[1].

Product Specifications

CAS Number

2647949-48-0

UNSPSC

12352211

Target

TGF-β Receptor

Related Pathways

TGF-beta/Smad

Field of Research

Metabolic Disease; Cancer

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CN1N=C(C(C2=C3C=CC=CC3=NC=C2)=C1)C4=CC=CC(C)=N4)NCC5=C(F)C=CC=C5F

Molecular Formula

C27H21F2N5O

Molecular Weight

469.49

References & Citations

[1]Ramón BOSSER ARTAL, et al. Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5. Patent. WO2021105317, 2021-06-03.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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