Ontunisertib
Ontunisertib (Example 26) is an inhibitor of TGFβ receptor I/ALK5 (TGFβRI/ALK5), with IC50 values ranging from 100 to 500 nM for TGFβRI and an IC50 value of ≤100 nM for ALK5. Ontunisertib can be used in research on gastrointestinal diseases, as well as diseases and cancers related to fibrotic conditions in the skin and eyes[1].
Product Specifications
CAS Number
[2647949-48-0]
UNSPSC
12352211
Target
TGF-β Receptor
Related Pathways
TGF-beta/Smad
Field of Research
Metabolic Disease; Cancer
Concentration
10mM
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CN1N=C(C(C2=C3C=CC=CC3=NC=C2)=C1)C4=CC=CC(C)=N4)NCC5=C(F)C=CC=C5F
Molecular Formula
C27H21F2N5O
Molecular Weight
469.49
References & Citations
[1]Ramón BOSSER ARTAL, et al. Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5. Patent. WO2021105317, 2021-06-03.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
