Lomonitinib
Lomonitinib is a highly potent and selective pan-FLT3/IRAK4 inhibitor with antitumor activity. Lomonitinib is promising for research of myeloid leukemia[1].
Product Specifications
CAS Number
[2923221-56-9]
UNSPSC
12352005
Target
FLT3; IRAK
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC(C=CC(C(C1=C2C3=C(N=C1)C=CC=C3)=NN2C4=CC=C5C(CNCC5)=C4)=C6)=C6OC
Molecular Formula
C27H24N4O2
Molecular Weight
436.51
References & Citations
[1]Byrd J C, et al. A Randomized Placebo-Controlled Phase 1 Trial in Healthy Volunteers Investigating the Safety, Pharmacokinetics and Pharmacodynamics of a Novel FLT3/IRAK4 Inhibitor, Lomonitinib (ZE46-0134) [J]. Blood, 2024, 144: 1396.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Curated Selection
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