Famlasertib
Famlasertib is a potent, brain-penetrant MAP4K inhibitor with IC50s value of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively. Famlasertib shows motor neuron protection and anti-inflammatory properties. Famlasertib can be used for the study of amyotrophic lateral sclerosis (ALS) [1][2].
Product Specifications
CAS Number
2375591-69-6
Product Name Alternative
Prostetin/12k
UNSPSC
12352101
Target
MAP4K; Mixed Lineage Kinase
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC(Cl)=CC=C5)N=C3
Molecular Formula
C26H27ClN4O
Molecular Weight
446.97
References & Citations
[1]Moreno R, et al. The emerging role of mixed lineage kinase 3 (MLK3) and its potential as a target for neurodegenerative diseases therapies. Eur J Med Chem. 2023 Sep 5;257:115511.|[2]Bos PH, et al. Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents. Cell Chem Biol. 2019 Dec 19;26 (12) :1703-1715.e37.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK
Available Sizes
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