Famlasertib

Famlasertib is a potent, brain-penetrant MAP4K inhibitor with IC50s value of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively. Famlasertib shows motor neuron protection and anti-inflammatory properties. Famlasertib can be used for the study of amyotrophic lateral sclerosis (ALS) [1][2].

Product Specifications

CAS Number

[2375591-69-6]

Product Name Alternative

Prostetin/12k

UNSPSC

12352101

Target

MAP4K; Mixed Lineage Kinase

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC(Cl)=CC=C5)N=C3

Molecular Formula

C26H27ClN4O

Molecular Weight

446.97

References & Citations

[1]Moreno R, et al. The emerging role of mixed lineage kinase 3 (MLK3) and its potential as a target for neurodegenerative diseases therapies. Eur J Med Chem. 2023 Sep 5;257:115511.|[2]Bos PH, et al. Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents. Cell Chem Biol. 2019 Dec 19;26 (12) :1703-1715.e37.