AA-BR-157
AA-BR-157 is a PROTAC degrader for metallothionein 2A (MT2A) with a DC50 of 190 nM. AA-BR-157 downregulates the cytoskeleton and cell motility regulating protein DIAPH3, inhibits the migration of MDA-MB-231 and U-87 MG. AA-BR-157 regulates the zinc homeostasis in MDA-MB-231[1]. (Pink: ligand for target protein MT2A ligand 1 ; Black: linker (HY-119429) ; Blue: ligand for VHL E3 ligase (HY-125845) )
Product Specifications
UNSPSC
12352211
Target
PROTACs
Related Pathways
PROTAC
Field of Research
Cancer
Purity
96.47
Smiles
O=C(NCC1=NC2=CC(C3=CC=CC(C(N4CCN(C(C=C)=O)CC4)=O)=C3)=CC=C2S1)CCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O
Molecular Formula
C56H70N8O11S2
Molecular Weight
1095.33
References & Citations
[1]Racioppo B, et al., Chemoproteomics-Enabled De Novo Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer. J Am Chem Soc. 2025 Mar 5;147 (9) :7817-7828.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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