JNJ-54082730
JNJ-54082730 (Compound 1) is the orally active inhibitor for phosphodiesterase (PDE) that inhibits PDE2A, PDE3B, and PDE10A2 with IC50s of 0.95 nM, 6.17 μM (pIC50=5.21) and 87.1 nM (pIC50=7.06), respectively. JNJ-54082730 modulates the activity of AMPA receptor, enhance the synaptic plasticity and promotes the learning and memory function in rats models. JNJ-54082730 can cross blood-brain barrier[1].
Product Specifications
CAS Number
[2097493-39-3]
UNSPSC
12352005
Target
IGluR; Phosphodiesterase (PDE)
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
C[C@H]1[C@@H](CN(CC1)C(C2=CC(C)=NC(C)=C2)=O)C3=CC(C(F)F)=NC4=NC=NN34
Molecular Formula
C20H22F2N6O
Molecular Weight
400.43
References & Citations
[1]Buijnsters P, et al., [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-7-YL COMPOUND. WO2017076900
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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