PROTAC BTK Degrader-13

PROTAC BTK Degrader-13 (Compound 25) is the PROTAC degrader for BTK with a DC50 of 0.27 μM. PROTAC BTK Degrader-13 inhibits the activity of BTK with an IC50 of 0.44 μM, inhibits IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 μM. PROTAC BTK Degrader-13 inhibits p38 MAPK signaling pathway, block the activation of the BCR (B cell receptor) signaling pathway[1]. (Pink: ligand for target protein BTK ligand 15 (HY-168965) ; Black: linker (HY-Y0524) ; Blue: ligand for E3 ligase cereblon (HY-103596) )

Product Specifications

UNSPSC

12352211

Target

Btk; Itk; p38 MAPK; PROTACs

Related Pathways

MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C1NC2=NC=C(C3=CC=C(OCO4)C4=C3)C=C2C15CCN(CCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)CC5

Molecular Formula

C33H30N6O7

Molecular Weight

622.63

References & Citations

[1]Rampeesa NK, et al., Identification of a novel Azaspirooxindolinone-based PROTAC for selective BTK degradation and enhanced anticancer activity. Bioorg Chem. 2025 Apr;157:108316.