ROS inducer 8
ROS inducer 8 (Compound 11g) is the inhibitor for glutathione (GSH), that induces the ROS accumulation in Enterococcus faecalis, thereby exhibiting antibacterial activity. ROS inducer 8 disrupts the biofilm, inhibits S. aureus and E. faecalis with MIC of 8 μg/mL and 2 μg/mL, exhibits post-antibiotic effect. ROS inducer 8 exhibits low hemolytic toxicity to sheep erythrocytes (HC50 > 1280 μg/mL) [1].
Product Specifications
UNSPSC
12352101
Target
Bacterial; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Smiles
CN(CC(N1CCN(C2=CC=C(N3C[C@H](CNC(C)=O)OC3=O)C=C2F)CC1)=O)CC4=CC=C([N+]([O-])=O)C=C4
Molecular Formula
C26H31FN6O6
Molecular Weight
542.56
References & Citations
[1]Ampomah-Wireko M, et al., Design, synthesis and antibacterial evaluation of oxazolidinone derivatives containing N-methylglycyl or quaternary ammonium salts. Bioorg Med Chem. 2025 Mar 2;122:118144.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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