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ANXA3 degrader 1

ANXA3 degrader 1 (Compound 18a5) is a highly selective ANXA3 degrader with cancer cell inhibition activity. ANXA3 degrader 1 displays excellent inhibitory effect in a triple-negative breast cancer (TNBC) tumor xenograft model (TGI=96%) [1].

Product Specifications

UNSPSC

12352005

Target

Annexin A

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(C)N1C2=CC=CC=C2C(C3=CC=CC=C3)=NC(NC(SCC(N4CCN(C5=NC=CC=C5)CC4)=O)=S)C1=O

Molecular Formula

C30H32N6O2S2

Molecular Weight

572.74

References & Citations

[1]Liu K, et al. Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2025 Mar 13;68 (5) :5358-5381.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AnxA3

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