DP-15

DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models[1]. (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695) ; Black: linker (HY-W262798) ; Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095) )

Product Specifications

CAS Number

[3033837-71-4]

UNSPSC

12352005

Target

Apoptosis; Epigenetic Reader Domain; PROTACs

Related Pathways

Apoptosis; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCN(CC4)CC5CCN(C6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)C9=NN=C(C)N29

Molecular Formula

C42H44ClN9O5S

Molecular Weight

822.37

References & Citations

[1]Xu Y, et al., Discovery of highly potent dual GSPT1/BRD4 degraders with anti-AML activity. Eur J Med Chem. 2025 Apr 15;288:117381.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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