KWR137
KWR137 is a WRN degrader, with an IC50 of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI50 of 509 nM in SW48 cells and a GI50 of 824 μM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research[1].
Product Specifications
UNSPSC
12352211
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
ClC1=CC(C(F)(F)F)=CC=C1NC(CN2C(CC)=C(N3CCN(C(C(N4)=CC5=C4C=CC=N5)=O)CC3)C(N6C2=NC(C7=CCOCC7)=N6)=O)=O
Molecular Formula
C33H31ClF3N9O4
Molecular Weight
710.11
References & Citations
[1]Moon B, et al. Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers. Bioorg Med Chem Lett. 2025 Feb 15;120:130141.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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