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KWR095

KWR095 is an orally active WRN inhibitor with an IC50 of 0.032 μM for WRN ATPase. KWR095 can impede the duplex unwinding activity of WRN and inhibit the proliferation of tumor cells. KWR095 has anti-tumor activity[1].

Product Specifications

CAS Number

3057980-16-9

UNSPSC

12352211

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

ClC1=CC(C(F)(F)F)=CC=C1NC(CN2C(CC)=C(N3CCN(C(C4=NC=CC5=C4NC=C5)=O)CC3)C(N6C2=NC(C7=CCOCC7)=N6)=O)=O

Molecular Formula

C33H31ClF3N9O4

Molecular Weight

710.11

References & Citations

[1]Moon B, et al. Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers. Bioorg Med Chem Lett. 2025 Feb 15;120:130141.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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