KWR095
KWR095 is an orally active WRN inhibitor with an IC50 of 0.032 μM for WRN ATPase. KWR095 can impede the duplex unwinding activity of WRN and inhibit the proliferation of tumor cells. KWR095 has anti-tumor activity[1].
Product Specifications
CAS Number
3057980-16-9
UNSPSC
12352211
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
ClC1=CC(C(F)(F)F)=CC=C1NC(CN2C(CC)=C(N3CCN(C(C4=NC=CC5=C4NC=C5)=O)CC3)C(N6C2=NC(C7=CCOCC7)=N6)=O)=O
Molecular Formula
C33H31ClF3N9O4
Molecular Weight
710.11
References & Citations
[1]Moon B, et al. Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers. Bioorg Med Chem Lett. 2025 Feb 15;120:130141.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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