ATX inhibitor 25
ATX inhibitor 25 (Compound 29) is an orally active Autotaxin inhibitor with an IC50 of 1.08 nM. ATX inhibitor 25 exhibits excellent in vitro metabolic stability, with a t1/2 of more than 170 minutes. In the bleomycin -induced pulmonary fibrosis mouse model, orally administered ATX inhibitor 25 shows anti-fibrotic effects[1].
Product Specifications
CAS Number
2951100-44-8
UNSPSC
12352211
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC1=C(C(NC2=CC(C(O)=O)=C(F)C=C2)=O)C3=CC(OC)=C(Cl)C=C3N1C4=CN(COC)N=C4
Molecular Formula
C23H20ClFN4O5
Molecular Weight
486.88
References & Citations
[1]Ma D, et al. Development of potent indole-3-carboxamide autotaxin inhibitors with preferred lipophilicity for in vivo treatment of pulmonary fibrosis. Eur J Med Chem. 2025 Apr 15;288:117398.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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