SHP1 activator 1

SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; Fluorescent Dye; Phosphatase; SHP1; STAT

Related Pathways

Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1OC2=CC(N(CC)CC)=CC=C2C=C1C(NC3=CC=C(C(NCCN(CC)CC)=O)C=C3)=O

Molecular Formula

C27H34N4O4

Molecular Weight

478.58

References & Citations

[1]Mu XY, et al., Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators. Eur J Med Chem. 2025 Apr 15;288:117394.