NQO2-IN-1

NQO2-IN-1 (Compound 20b) is the inhibitor for quinone oxidoreductase (NQO) that inhibits NQO2 with an IC50 of 95 nM. NQO2-IN-1 overcomes the resistance of NSCLC cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by induction of ROS and apoptosis[1].

Product Specifications

CAS Number

[2920687-14-3]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Purity

98.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=CC(N=C2)=C(C=C1)C=C2C3=CC(OC)=C(OC)C(OC)=C3

Molecular Formula

C18H18N2O3

Molecular Weight

310.35

References & Citations

[1]Qi SJ, et al., Discovery of potent quinone oxidoreductase 2 inhibitors to overcome TRAIL resistance of non-small cell lung cancer. Eur J Med Chem. 2025 Feb 16;288:117382.