NQO2-IN-1
NQO2-IN-1 (Compound 20b) is the inhibitor for quinone oxidoreductase (NQO) that inhibits NQO2 with an IC50 of 95 nM. NQO2-IN-1 overcomes the resistance of NSCLC cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by induction of ROS and apoptosis[1].
Product Specifications
CAS Number
[2920687-14-3]
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Purity
98.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=CC(N=C2)=C(C=C1)C=C2C3=CC(OC)=C(OC)C(OC)=C3
Molecular Formula
C18H18N2O3
Molecular Weight
310.35
References & Citations
[1]Qi SJ, et al., Discovery of potent quinone oxidoreductase 2 inhibitors to overcome TRAIL resistance of non-small cell lung cancer. Eur J Med Chem. 2025 Feb 16;288:117382.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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