EXQ-2d
EXQ-2d is the inhibitor for tankyrase and inhibits TNKS1 and TNKS2 with an IC50 of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86) . EXQ-2d inhibits WNT/β-catenin signaling pathway with IC50 of 515 nM. EXQ-2d exhibits anti-proliferative activity in cancer cells COLO 320DM and RKO with GI50 of 4.9 μM and 77 μM[1].
Product Specifications
UNSPSC
12352005
Target
PARP; Wnt; β-catenin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1NC(C2=CC=C(C(C)(C)C)C=C2)=NC3=C([N+]([O-])=O)C=CC=C31
Molecular Formula
C18H17N3O3
Molecular Weight
323.35
References & Citations
[1]Bosetti C, et al., Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors. Eur J Med Chem. 2025 Feb 15;288:117397.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNKS1/PARP5A; TNKS2/PARP5B
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