Wnt/β-catenin activator 1

Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC50 of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model[1].

Product Specifications

UNSPSC

12352101

Target

Wnt; β-catenin

Related Pathways

Stem Cell/Wnt

Field of Research

Metabolic Disease

Smiles

CC1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)C3=CC4=C(C(C(O)=O)=C3)C=C(C=C4)F

Molecular Formula

C26H19FO2

Molecular Weight

382.43

References & Citations

[1]Singh R, et al., Design, synthesis, and biological evaluation of novel quinoline carboxylic acid based styryl/alkyne hybrid molecule as a potent anti-adipogenic and antidyslipidemic agent via activation of Wnt/β-catenin pathway. Eur J Med Chem. 2025 Feb 14;288:117346.