Wnt/β-catenin activator 1
Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC50 of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model[1].
Product Specifications
UNSPSC
12352101
Target
Wnt; β-catenin
Related Pathways
Stem Cell/Wnt
Field of Research
Metabolic Disease
Smiles
CC1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)C3=CC4=C(C(C(O)=O)=C3)C=C(C=C4)F
Molecular Formula
C26H19FO2
Molecular Weight
382.43
References & Citations
[1]Singh R, et al., Design, synthesis, and biological evaluation of novel quinoline carboxylic acid based styryl/alkyne hybrid molecule as a potent anti-adipogenic and antidyslipidemic agent via activation of Wnt/β-catenin pathway. Eur J Med Chem. 2025 Feb 14;288:117346.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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