Keap1-Nrf2-IN-25

Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor (IC50 of 0.55 μM) with Keap1 binding affinity (Kd of 0.50 μM) . Keap1-Nrf2-IN-25 activates Nrf2, reduces ROS and pro-inflammatory cytokines (IL-1β, IL-6) . Keap1-Nrf2-IN-25 exerts protective effects against DSS (HY-116282) -induced colitis[1].

Product Specifications

CAS Number

[3100306-80-4]

UNSPSC

12352005

Target

Interleukin Related; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC(CN(S(=O)(C1=C(C)C=C(C)C=C1C)=O)C2=CC=C(N[C@H](CC(O)=O)C)C3=CC=CC=C32)=O

Molecular Formula

C25H28N2O6S

Molecular Weight

484.56

References & Citations

[1]Zhao Z, et al. Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management. Eur J Med Chem. 2025 Feb 13;288:117384.