Insecticidal agent 19
Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 μM and 3.78 μM[1].
Product Specifications
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; Parasite
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C(C1N2N=C(C=C2C3=CC=C(C=C3)Cl)C4=C(C5=C(OC4=O)C=CC=C5)O)NC(C=C6)=C1C=C6[N+]([O-])=O
Molecular Formula
C26H15ClN4O6
Molecular Weight
514.87
References & Citations
[1]Batran RZ, et al., Synthesis and mechanistic insights of Coumarinyl-Indolinone hybrids as potent inhibitors of Leishmania major. Eur J Med Chem. 2025 Feb 12;288:117392.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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