9-AMN
9-AMN is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC50 of 4.55 µM and 4.15 µM. 9-AMN inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC50 of 1.04 µM and 2.35 µM[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1C(C(N)=O)=C(O)[C@@]2(O)C(C3=C(O)C4=C(O)C(N)=CC(N(C)C)=C4C[C@H]3C[C@H]2[C@@H]1N(C)C)=O
Molecular Formula
C23H28N4O7
Molecular Weight
472.49
References & Citations
[1]Pandey K, et al., 9-aminominocycline potentiates the efficacy of EIDD-1931 and PF-332 by targeting the papain like protease enzyme of SARS-CoV-2. Sci Rep. 2025 Feb 15;15 (1) :5671.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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