Jun13296
Jun13296 is an orally active quinoline SARS-CoV-2 papain-like protease inhibitor (IC50 = 0.13 µM, Ki = 8.8 nM) . Jun13296 exhibits potent inhibition against SARS-CoV-2 variants and Nirmatrelvir (HY-138687) -resistant mutants. Jun13296 improves lung viral titers, and prevents lung tissue damage in a SARS-CoV-2 infection model[1].
Product Specifications
CAS Number
[3063566-68-4]
UNSPSC
12352211
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N[C@@H](C1=CC(C2=CN(C)N=C2)=NC3=CC=CC=C13)C)C4=CC(N5C[C@@](N6C)([H])CC[C@@]6([H])C5)=CC=C4C
Molecular Formula
C30H34N6O
Molecular Weight
494.63
References & Citations
[1]Jadhav P, et al. Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates. Nat Commun. 2025 Feb 13;16 (1) :1604.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6312584-01 0.1 mL
KCNJ6, ID (KCNJ6, GIRK2, KATP2, KCNJ7, G protein-activated inward rectifier potassium channel 2, BIR1, Inward rectifier K(+) channel Kir3.2, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6) (MaxLight 550)
Ask
View Details MBS6312584-02 5x 0.1 mL
KCNJ6, ID (KCNJ6, GIRK2, KATP2, KCNJ7, G protein-activated inward rectifier potassium channel 2, BIR1, Inward rectifier K(+) channel Kir3.2, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6) (MaxLight 550)
Ask
View Details 
MBS2601581-01 48 Well
Rabbit Soluble Cluster of differentiation 28 (sCD28) ELISA Kit
Ask
View Details MBS2601581-02 96 Well
Rabbit Soluble Cluster of differentiation 28 (sCD28) ELISA Kit
Ask
View Details