ML-B01
ML-B01 is the orally active inhibitor for Akt and PKA with the IC50 of 2 nM and 136 nM. ML-B01 exhibits good ability to penetrate the blood-brain barrier (BBB) in the mouse brain[1].
Product Specifications
UNSPSC
12352005
Target
Akt; PKA
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C(N1CCN(C2=C([C@H](C)C[C@H]3Cl)C3=NC=N2)CC1)[C@@H](C4=CC=C(Cl)C=C4)CNC(C)C
Molecular Formula
C24H31Cl2N5O
Molecular Weight
476.44
References & Citations
[1]Wu Y, et al., Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator. Nat Chem Biol. 2025 Feb 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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