ML-B01
ML-B01 is the orally active inhibitor for Akt and PKA with the IC50 of 2 nM and 136 nM. ML-B01 exhibits good ability to penetrate the blood-brain barrier (BBB) in the mouse brain[1].
Product Specifications
UNSPSC
12352005
Target
Akt; PKA
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C(N1CCN(C2=C([C@H](C)C[C@H]3Cl)C3=NC=N2)CC1)[C@@H](C4=CC=C(Cl)C=C4)CNC(C)C
Molecular Formula
C24H31Cl2N5O
Molecular Weight
476.44
References & Citations
[1]Wu Y, et al., Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator. Nat Chem Biol. 2025 Feb 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC401125-100 1x 100 µL
Arginase 1 (Hepatocellular Carcinoma Marker) (ARG1/1125), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402266-500 1x 500 µL
Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402025-500 1x 500 µL
MMP9 (MMP9/2025R), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472342-500 1x 500 µL
Calcineurin B / PPP3R1 (CALNB/2342), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details