CTT2274

CTT2274 is a prodrug of MMAE (HY-15162) . CTT2274 is composed of a prostate-specific membrane antigen (PSMA) -binding scaffold, a biphenyl motif, a pH-sensitive phosphoramidate linker, and MMAE payload. CTT2274 shows selective binding to PSMA and delivers MMAE. CTT2274 inhibits prostate cancer[1].

Product Specifications

UNSPSC

12352211

Target

PSMA

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O[C@H]([C@@H](C)NC([C@H](C)[C@@H](OC)[C@@H]1CCCN1C(C[C@@H](OC)[C@@H](N(C)C([C@@H](NC([C@@H](N(C)C(OCC2=CC=C(OC(N(C)CCN(C)P(OCC[C@@H](C(O)=O)NC(C3=CC=C(CN4N=NC5=C4C6=C(C=CC=C6)CN(C(CCC(N[C@@H](CC7=CC=C(C8=CC=CC=C8)C=C7)C(NCCCCCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCCOP(N[C@H](C(O)=O)CCC(O)=O)(O)=O)=O)=O)=O)=O)=O)C9=C5C=CC=C9)C=C3)=O)(O)=O)=O)C=C2)=O)C(C)C)=O)C(C)C)=O)[C@H](CC)C)=O)=O)C%10=CC=CC=C%10

Molecular Formula

C119H159N17O33P2

Molecular Weight

2417.58

References & Citations

[1]Bomba HN, et al. A Unique Prodrug Targeting the Prostate-Specific Membrane Antigen for the Delivery of Monomethyl Auristatin E. Bioconjug Chem. 2025 Feb 19;36 (2) :169-178.Bomba HN, et al. A Unique Prodrug Targeting the Prostate-Specific Membrane Antigen for the Delivery of Monomethyl Auristatin E. Bioconjug Chem. 2025 Feb 19;36 (2) :169-178.