PROTAC c-Met degrader-3

PROTAC c-Met degrader-3 (Compound 22b) is a c-Met PROTAC degrader. PROTAC c-Met degrader-3 promotes ubiquitination and degradation of c-Met (DC50 of 0.59 nM in EBC-1 cells) . PROTAC c-Met degrader-3 can be used for the research of lung cancer (Pink: c-Met ligand (HY-14721) ; Blue: E3 ligase CRBN ligand (HY-W249500) ; linker + E3 ligase ligand (HY-168911) ) [1].

Product Specifications

UNSPSC

12352211

Target

C-Met/HGFR; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(N1)N(C2=CC(C(N3CCC4(CCN(CC4)C(CN5CCC(COC6=CN=C(N=C6)C7=CC=CC(CN8N=C(C=CC8=O)C9=CC(C#N)=CC=C9)=C7)CC5)=O)CC3)=O)=CC=C2OC)CCC1=O

Molecular Formula

C51H54N10O7

Molecular Weight

919.04

References & Citations

[1]Qiu X, et al. Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy. J Med Chem. 2025 Feb 13;68 (3) :2815-2839.