PROTAC c-Met degrader-3
PROTAC c-Met degrader-3 (Compound 22b) is a c-Met PROTAC degrader. PROTAC c-Met degrader-3 promotes ubiquitination and degradation of c-Met (DC50 of 0.59 nM in EBC-1 cells). PROTAC c-Met degrader-3 can be used for the research of lung cancer (Pink: c-Met ligand ; Blue: E3 ligase CRBN ligand (HY-W249500) ; linker + E3 ligase ligand (HY-168911) ).
Product Specifications
UNSPSC
12352211
Target
C-Met/HGFR; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N1)N(C2=CC(C(N3CCC4(CCN(CC4)C(CN5CCC(COC6=CN=C(N=C6)C7=CC=CC(CN8N=C(C=CC8=O)C9=CC(C#N)=CC=C9)=C7)CC5)=O)CC3)=O)=CC=C2OC)CCC1=O
Molecular Formula
C51H54N10O7
Molecular Weight
919.04
References & Citations
[1]Qiu X, et al. Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy. J Med Chem. 2025 Feb 13;68 (3) :2815-2839.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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