LIJTF500025
LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC50 values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer[1].
Product Specifications
CAS Number
2838087-03-7
UNSPSC
12352211
Target
LIM Kinase (LIMK)
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
NC(C1=C2C(C(N([C@@H]3C(N(C4=CC=C(Cl)C=C4OC3)C)=O)CC2)=O)=NN1CC5=CC=CC=C5)=O
Molecular Formula
C24H22ClN5O4
Molecular Weight
479.92
References & Citations
[1]Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65 (20) :13705-13713.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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