LIJTF500025

LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC50 values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2838087-03-7]

UNSPSC

12352211

Target

LIM Kinase (LIMK)

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

NC(C1=C2C(C(N([C@@H]3C(N(C4=CC=C(Cl)C=C4OC3)C)=O)CC2)=O)=NN1CC5=CC=CC=C5)=O

Molecular Formula

C24H22ClN5O4

Molecular Weight

479.92

References & Citations

[1]Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65 (20) :13705-13713.