Proteasome-IN-7

Proteasome-IN-7 (Compound 6f) is an epoxyketone macrocyclic peptidyl proteasome inhibitor (IC50 value of 37.92 nM for 20S proteasome ChT-L subunit) . Proteasome-IN-7 displays robust antiproliferative effects against multiple myeloma, acute lymphoblastic leukemia and non-small cell lung cancer[1].

Product Specifications

UNSPSC

12352211

Target

Proteasome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

COC(/C=C(C1=C2C=CC=CC2=C3SC[C@H](NC([C@@H](NC([C@H](CCCCN31)NC(C4=CC=CN=C4)=O)=O)CCC5=CC=CC=C5)=O)C(N[C@H](C([C@]6(CO6)C)=O)CC(C)C)=O)\C(OC)=O)=O

Molecular Formula

C48H56N6O10S

Molecular Weight

909.06

References & Citations

[1]Zeng G, et al. Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides. Bioorg Chem. 2025 Mar;156:108180.