FAK-IN-24

FAK-IN-24 (Compound 9f) is a FAK inhibitor (IC50: 0.815 nM) . FAK-IN-24 induces DNA damage and apoptosis. FAK-IN-24 has anti-glioblastoma activity. FAK-IN-24 inhibits proliferation of glioblastoma cell lines U87-MG (IC50 = 15 nM) and U251 (IC50 = 20 nM) . FAK-IN-24 inhibits tumor growth in U87-MG xenograft model[1].

Product Specifications

CAS Number

[3062175-62-3]

UNSPSC

12352211

Target

Apoptosis; FAK

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(CCCC1=CC=C(N(CCCl)CCCl)C=C1)OCCN2CCN(CC2)C3=CC=C(NC4=NC=C(C(F)(F)F)C(NC5=C(C(NC)=O)C=CC=C5)=N4)C=C3

Molecular Formula

C39H45Cl2F3N8O3

Molecular Weight

801.73

References & Citations

[1]Wei Y, et al. Discovery of noncovalent diaminopyrimidine-based Inhibitors for glioblastoma via a dual FAK/DNA targeting strategy. Eur J Med Chem. 2025 Mar 15;286:117288.