CDK9 autophagic degrader 1
CDK9 autophagic degrader 1 (Compound 28) is a ATTEC degrader that can be used to degrade CDK9 and also affects the levels of the associated Cyclin T1. CDK9 autophagic degrader 1 shows over 80% CDK9 inhibition rate at 100 nM[1]. (Pink: LC3B ligand ; Black: linker (HY-W017758) ; Blue: target protein ligand (HY-10008) ; linker + target protein ligand (HY-168898) )
Product Specifications
CAS Number
3066836-42-5
UNSPSC
12352211
Target
ATTECs; CDK
Related Pathways
Autophagy; Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C(N1CC2=CC=CC=C2)N(CCCN3CCC(C(NC4=NC=C(SCC5=NC=C(C(C)(C)C)O5)S4)=O)CC3)C6=NC=CC=C6C1=O
Molecular Formula
C34H39N7O4S2
Molecular Weight
673.85
References & Citations
[1]Yanping Zeng, et al. Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations. Eur J Med Chem. 2025 Jan 19:287:117293.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Frequently Asked Questions
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