CDK9 autophagic degrader 1

CDK9 autophagic degrader 1 (Compound 28) is a ATTEC degrader that can be used to degrade CDK9 and also affects the levels of the associated Cyclin T1. CDK9 autophagic degrader 1 shows over 80% CDK9 inhibition rate at 100 nM[1]. (Pink: LC3B ligand (HY-168897) ; Black: linker (HY-W017758) ; Blue: target protein ligand (HY-10008) ; linker + target protein ligand (HY-168898) )

Product Specifications

CAS Number

[3066836-42-5]

UNSPSC

12352211

Target

ATTECs; CDK

Related Pathways

Autophagy; Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C(N1CC2=CC=CC=C2)N(CCCN3CCC(C(NC4=NC=C(SCC5=NC=C(C(C)(C)C)O5)S4)=O)CC3)C6=NC=CC=C6C1=O

Molecular Formula

C34H39N7O4S2

Molecular Weight

673.85

References & Citations

[1]Yanping Zeng, et al. Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations. Eur J Med Chem. 2025 Jan 19:287:117293.