C-Fos-IN-1

C-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell) . c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1].

Product Specifications

UNSPSC

12352211

Target

AP-1; Apoptosis; ERK

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

C=C1CCC2([C@@](C)([C@@H](CC[C@]2([C@@H]1/C=C/C(C(N/3)=O)=CC3=C\C4=CC=C(C=C4)C)C)O)CO)[H]

Molecular Formula

C28H35NO3

Molecular Weight

433.58

References & Citations

[1]Zhang H, et al. The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway. Eur J Med Chem. 2025 Mar 15;286:117291.