CT-1
CT-1 is a derivative of Cryptotanshinone. CT-1 is a ferroptosis inducer. CT-1 promotes the interaction between NCOA4 and ferritin by targeting FTH1, triggering ferritinophagy-mediated ferroptosis. CT-1 has anticancer activity against triple-negative breast cancer (TNBC). CT-1 induces ferroptosis in both N2-type tumor-associated neutrophils (TANs) and TNBC cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Purity
99.47
Smiles
O=C(C1(C)C)C=CC2=C1C=CC3=C2C(OC(C)=O)=C(OC(C)=O)C4=C3OC[C@@H]4C
Molecular Formula
C23H22O6
Molecular Weight
394.42
References & Citations
[1]Liu Y, et al. Dual ferroptosis induction in N2-TANs and TNBC cells via FTH1 targeting: A therapeutic strategy for triple-negative breast cancer. Cell Rep Med. 2025 Jan 21;6 (1) :101915.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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