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TRF2-IN-1

TRF2-IN-1 (compound F2) is a potent telomere repeat-binding factor 2 (TRF2) inhibitor. TRF2-IN-1 shows antiproliferative activity. TRF2-IN-1 induces apoptosis. TRF2-IN-1 directly bind to the TRF2TRFH domain and selectively inhibits TRF2 protein expression and telomeric localization. TRF2-IN-1 shows anticancer activity. TRF2-IN-1 has the potential for the research of osteosarcoma[1].

Product Specifications

UNSPSC

12352101

Target

Apoptosis; Telomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(/C=C/C1=CC=CC(Br)=C1)C2=C(OC)C=C(OC)C=C2OC

Molecular Formula

C18H17BrO4

Molecular Weight

377.23

References & Citations

[1]Wang K, et al. Design, synthesis, and biological evaluation of Flavokavain B derivatives as potent TRF2 inhibitors for the treatment of Osteosarcoma. Eur J Med Chem. 2025 Mar 15;286:117279.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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