COX-2-IN-52
COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. COX-2-IN-52 can inhibit the release of NO in cells and has anti-inflammatory activity. COX-2-IN-52 has high gastrointestinal safety and can be used in the research of oral anti-inflammatory drugs[1].
Product Specifications
UNSPSC
12352101
Target
COX
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(O)CSC1=NN=C(C2=CC=C(S(=O)(N)=O)C=C2)N1C3=CC=C(I)C=C3
Molecular Formula
C16H13IN4O4S2
Molecular Weight
516.33
References & Citations
[1]Song ZJ, et al. Design, synthesis, and evaluation of carboxylic acid-substituted celecoxib isosteres as potential anti-inflammatory agents. Eur J Med Chem. 2025 Mar 15;286:117286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
Curated Selection
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