COX-2-IN-52

COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. COX-2-IN-52 can inhibit the release of NO in cells and has anti-inflammatory activity. COX-2-IN-52 has high gastrointestinal safety and can be used in the research of oral anti-inflammatory drugs[1].

Product Specifications

UNSPSC

12352101

Target

COX

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(O)CSC1=NN=C(C2=CC=C(S(=O)(N)=O)C=C2)N1C3=CC=C(I)C=C3

Molecular Formula

C16H13IN4O4S2

Molecular Weight

516.33

References & Citations

[1]Song ZJ, et al. Design, synthesis, and evaluation of carboxylic acid-substituted celecoxib isosteres as potential anti-inflammatory agents. Eur J Med Chem. 2025 Mar 15;286:117286.