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ZSH-512

ZSH-512 is a potent RARγ inhibitor. ZSH-512 shows antiproliferation activity. ZSH-512 induces apoptosis. ZSH-512 decreases CD133, NANOG, SOX2, and EPCAM protein expression. ZSH-512 shows anticancer activity. ZSH-512 has the potential for the research of colorectal cancer[1].

Product Specifications

CAS Number

[2923210-02-8]

UNSPSC

12352005

Target

Apoptosis; RAR/RXR

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

CCOC(C1=CN=C(N=C1N)C#CC2=CC3=C(S(CCC3(C)C)=O)C=C2)=O

Molecular Formula

C20H21N3O3S

Molecular Weight

383.46

References & Citations

[1]Suyao Li, et al. Novel cancer stem cell targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A mediated epigenetic reprogramming. ScienceDirect. 2025

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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