FMP
FMP is a Platinum (IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax) . FMP shows antiproliferative activity against breast cancer[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53; PARP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
COC1=CC=C(C2=COC3=CC(OCC(O[Pt](N)(O)(Cl)(Cl)N)=O)=CC=C3C2=O)C=C1
Molecular Formula
C18H18Cl2N2O7Pt
Molecular Weight
640.33
References & Citations
[1]Cai L, et al. Platinum (IV) Complexes Trigger Death Receptors and Natural Killer Cells to Suppress Breast Cancer. J Med Chem. 2025 Jan 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Caspase 3; Caspase 8
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