AZ14240475
AZ14240475 is a potent, selective, and brain-penetrant inhibitor of EGFR Ex20Ins mutants, with the pIC50 of 7.6. AZ14240475 plays an important role in cancer research[1].
Product Specifications
UNSPSC
12352101
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CC(N1CC2=C(C1)N(C3=CC=NC=N3)C(C4=C(F)C=C(F)C(OC5=NC=CC(Cl)=C5)=C4)=N2)=O
Molecular Formula
C23H15ClF2N6O2
Molecular Weight
480.85
References & Citations
[1]William McCoull, et al. Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations. J Med Chem. 2025 Jan 27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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