TrxR1 prodrug-1
TrxR1 prodrug-1 (compound 5u) is a potent inhibitor of TrxR1. TrxR1 prodrug-1 exhibits significant antitumor efficiency in nude mice and NSCLC organoids[1].
Product Specifications
UNSPSC
12352211
Target
Reactive Oxygen Species (ROS) ; TrxR
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
S=C(SC[C@@H]1[C@H]2[C@@H](/C=C(C[C@H]3C=C(C[C@@H]2OC1=O)C(O3)=O)\C)OC(NCCC)=O)N(C)C
Molecular Formula
C22H30N2O6S2
Molecular Weight
482.61
References & Citations
[1]Hui Ren, et al. Design of ROS-Triggered Sesquiterpene Lactone SC Prodrugs as TrxR1 Covalent Inhibitors for the Treatment of Non-Small Cell Lung Cancer. J Med Chem. 2025 Jan 27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrxR1
Curated Selection
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